Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants/S65W (c.194C>G)

S65W (c.194C>G)

CIViC ID: 1787 · Gene: VHL

Variant Summary

Also known as: C.194C>G,SER65TRP,RS5030826
HGVS: ENST00000256474.2:c.194C>G,NM_000551.3:c.194C>G,NP_000542.1:p.Ser65Trp,NC_000003.11:g.10183725C>G
Variant Type(s): missense_variant
Evidence Items: 15

Evidence Level Distribution

Level C: 15

Evidence Items

Showing CIViC evidence rows where gene = VHL and variant = S65W (c.194C>G).

Level	Type	Direction	Significance	Disease	Drugs	Rating
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Uncertain Significance	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Uncertain Significance	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Uncertain Significance	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Uncertain Significance	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Uncertain Significance	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Uncertain Significance	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		3
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		2
C	Predisposing	Supports	Predisposition	Von Hippel-Lindau Disease		2