CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/L89P (c.266T>C)

L89P (c.266T>C)

CIViC ID: 1793 · Gene: VHL

Variant Summary

Also known as
C.266T>C,LEU89PRO,RS5030807
HGVS
NM_000551.3:c.266T>C,NP_000542.1:p.Leu89Pro,NC_000003.11:g.10183797T>C,ENST00000256474.2:c.266T>C
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level C: 5

Evidence Items

Showing CIViC evidence rows where gene = VHL and variant = L89P (c.266T>C).

LevelTypeDirectionSignificanceDiseaseDrugsRating
CPredisposingSupportsUncertain SignificanceVon Hippel-Lindau Disease3
CPredisposingSupportsPredispositionVon Hippel-Lindau Disease2
CPredisposingSupportsPredispositionVon Hippel-Lindau Disease2
CPredisposingSupportsPredispositionVon Hippel-Lindau Disease2
CPredisposingSupportsUncertain SignificanceVon Hippel-Lindau Disease2