Variant Summary
- Also known as
- C.485G>A,CYS162TYR,RS397516444
- HGVS
- NM_000551.3:c.485G>A,NP_000542.1:p.Cys162Tyr,NC_000003.11:g.10191492G>A,ENST00000256474.2:c.485G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 4
Evidence Level Distribution
Level C: 4
Evidence Items
Showing CIViC evidence rows where gene = VHL and variant = C162Y (c.485G>A).
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | 3 | |
| C | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | 3 | |
| C | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | 3 | |
| C | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | 2 |