CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 183 · Gene: BAP1

Variant Summary

HGVS
—
Variant Type(s)
protein_altering_variant,loss_of_function_variant
Evidence Items
5

Evidence Level Distribution

Level B: 4Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = BAP1 and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsPoor OutcomeClear Cell Renal Cell Carcinoma5
BPrognosticSupportsPoor OutcomeRenal Cell Carcinoma5
BPrognosticSupportsPoor OutcomeClear Cell Renal Cell Carcinoma5
BPredictiveSupportsResistanceRenal Cell CarcinomaSunitinib,Everolimus4
DPredictiveSupportsSensitivity/ResponseUveal MelanomaTrichostatin A,Valproic Acid,Panobinostat,Vorinostat3