CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

P286R

CIViC ID: 1830 · Gene: POLE

Variant Summary

Also known as
PRO286ARG
HGVS
NM_006231.3:c.857C>G,NP_006222.2:p.Pro286Arg,NC_000012.11:g.133253184G>C,ENST00000320574.5:c.857C>G
Variant Type(s)
missense_variant
Evidence Items
1

Evidence Level Distribution

Level B: 1

Evidence Items

Showing CIViC evidence rows where gene = POLE and variant = P286R.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsBetter OutcomeColorectal Cancer3