Variant Summary
- HGVS
- —
- Variant Type(s)
- gene_variant,loss_of_function_variant
- Evidence Items
- 21
Evidence Level Distribution
Level A: 5Level B: 16
Evidence Items
Showing CIViC evidence rows where gene = BRCA1 and variant = Mutation.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| A | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Rucaparib | 5 |
| A | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Rucaparib | 5 |
| A | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Olaparib | 5 |
| A | Predictive | Supports | Sensitivity/Response | Castration-resistant Prostate Carcinoma | Olaparib | 4 |
| B | Predictive | Supports | Sensitivity/Response | Cancer | Olaparib | 4 |
| B | Predictive | Supports | Sensitivity/Response | Her2-receptor Negative Breast Cancer | Olaparib | 4 |
| B | Predictive | Supports | Sensitivity/Response | Pancreatic Cancer | Oxaliplatin,Cisplatin | 4 |
| B | Predictive | Supports | Sensitivity/Response | Ovarian Carcinoma | Platinum Compound | 3 |
| B | Predictive | Supports | Sensitivity/Response | Ovarian Carcinoma | Platinum Compound | 3 |
| B | Prognostic | Supports | Better Outcome | Ovarian Cancer | 3 | |
| B | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Cediranib,Olaparib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Triple-receptor Negative Breast Cancer | Cisplatin,Carboplatin | 3 |
| B | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Olaparib | 3 |
| B | Predictive | Supports | Resistance | Triple-receptor Negative Breast Cancer | Olaparib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Rucaparib | 3 |
| B | Prognostic | Supports | Better Outcome | Epithelial Ovarian Cancer | 3 | |
| B | Predictive | Supports | Sensitivity/Response | Pancreatic Cancer | Olaparib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Pancreatic Cancer | Cisplatin,Gemcitabine,Veliparib | 3 |
| B | Predictive | Does Not Support | Sensitivity/Response | Pancreatic Cancer | Veliparib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Rucaparib | 3 |
| A | Predictive | Supports | Sensitivity/Response | Ovarian Cancer | Olaparib | 1 |