CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Amplification

Amplification

CIViC ID: 187 · Gene: CCNE1

Variant Summary

HGVS
—
Variant Type(s)
transcript_amplification
Evidence Items
5

Evidence Level Distribution

Level B: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = CCNE1 and variant = Amplification.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseOvarian Serous CystadenocarcinomaAkt Inhibitor MK2206,Dinaciclib4
BPrognosticSupportsPoor OutcomeOvarian Carcinoma4
DPredictiveSupportsSensitivity/ResponseOvarian CarcinomaCamonsertib,Lunresertib3
DPredictiveSupportsSensitivity/ResponseEndometrial CarcinomaCamonsertib,Lunresertib3
DPredictiveSupportsResistanceEstrogen-receptor Positive Breast CancerPalbociclib3