Variant Summary
- HGVS
- —
- Variant Type(s)
- —
- Evidence Items
- 8
Evidence Level Distribution
Level B: 7Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = CCND1 and variant = Overexpression.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Diagnostic | Supports | Positive | Breast Cancer | 4 | |
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 4 | |
| B | Prognostic | Supports | Poor Outcome | Head And Neck Squamous Cell Carcinoma | 4 | |
| B | Prognostic | Supports | Poor Outcome | Mantle Cell Lymphoma | 4 | |
| B | Predictive | Supports | Resistance | Estrogen-receptor Positive Breast Cancer | Tamoxifen | 3 |
| B | Predictive | Does Not Support | Sensitivity/Response | Mantle Cell Lymphoma | Palbociclib | 2 |
| B | Prognostic | Supports | Poor Outcome | Childhood B-cell Acute Lymphoblastic Leukemia | 2 | |
| D | Predictive | Supports | Sensitivity/Response | Mantle Cell Lymphoma | Palbociclib | 1 |