Variant Summary
- Also known as
- MET541LEU,RS3822214
- HGVS
- NM_000222.2:c.1621A>C,NP_000213.1:p.Met541Leu,ENST00000288135.5:c.1621A>C,NC_000004.11:g.55593464A>C
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 1Level C: 1Level E: 1
Evidence Items
Showing CIViC evidence rows where gene = KIT and variant = M541L.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Diagnostic | Does Not Support | Positive | Chronic Myeloid Leukemia | 4 | |
| C | Predictive | Supports | Sensitivity/Response | Chronic Leukemia | Imatinib | 2 |
| E | Predictive | Supports | Sensitivity/Response | Colon Signet Ring Adenocarcinoma | Imatinib | 2 |