CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 206 · Gene: NOTCH1

Variant Summary

HGVS
—
Variant Type(s)
protein_altering_variant
Evidence Items
4

Evidence Level Distribution

Level A: 1Level B: 3

Evidence Items

Showing CIViC evidence rows where gene = NOTCH1 and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticDoes Not SupportPoor OutcomeChronic Lymphocytic Leukemia5
APrognosticSupportsPoor OutcomeChronic Lymphocytic Leukemia5
BPrognosticSupportsPoor OutcomeMantle Cell Lymphoma3
BPrognosticSupportsPoor OutcomeChronic Lymphocytic Leukemia2