CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Amplification

Amplification

CIViC ID: 212 · Gene: PIK3CA

Variant Summary

HGVS
—
Variant Type(s)
transcript_amplification
Evidence Items
6

Evidence Level Distribution

Level B: 1Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = PIK3CA and variant = Amplification.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseStomach CarcinomaAlpelisib3
BPrognosticSupportsPoor OutcomeGastric Adenocarcinoma3
CPredictiveSupportsSensitivity/ResponseEpithelial Ovarian CancerPictilisib2
DPredictiveSupportsResistanceHer2-receptor Positive Breast CancerTrastuzumab2
DPredictiveSupportsSensitivity/ResponseHer2-receptor Positive Breast CancerLapatinib,Dactolisib2
DPredictiveSupportsSensitivity/ResponseHead And Neck Squamous Cell CarcinomaTaselisib1