Variant Summary
- HGVS
- —
- Variant Type(s)
- loss_of_function_variant,transcript_variant
- Evidence Items
- 2
Evidence Level Distribution
Level B: 2
Evidence Items
Showing CIViC evidence rows where gene = SMAD4 and variant = Mutation.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Prognostic | Supports | Poor Outcome | Pancreatic Adenocarcinoma | 3 | |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab,Panitumumab | 2 |