CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Promoter Mutation

Promoter Mutation

CIViC ID: 220 · Gene: TERT

Variant Summary

Also known as
-124C>T,-146C>T
HGVS
—
Variant Type(s)
regulatory_region_variant
Evidence Items
7

Evidence Level Distribution

Level B: 6Level C: 1

Evidence Items

Showing CIViC evidence rows where gene = TERT and variant = Promoter Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsPoor OutcomeGlioblastoma4
CPrognosticSupportsPoor OutcomeChildhood Low-grade Glioma4
BPrognosticSupportsPoor OutcomeSkin Melanoma3
BDiagnosticSupportsPositiveThyroid Cancer3
BPrognosticSupportsPoor OutcomeThyroid Cancer3
BPrognosticSupportsPoor OutcomeGlioblastoma3
BDiagnosticSupportsPositiveBrain Glioma3