CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Deleterious Mutation

Deleterious Mutation

CIViC ID: 221 · Gene: TP53

Variant Summary

HGVS
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Variant Type(s)
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Evidence Items
7

Evidence Level Distribution

Level B: 5Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = TP53 and variant = Deleterious Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticDoes Not SupportPoor OutcomeLung Non-small Cell Carcinoma4
DPredictiveSupportsResistanceCancerMDM2 Inhibitor AMGMDS34
DPredictiveSupportsResistanceCancerRebemadlin4
BPredictiveSupportsResistanceLeukemiaRG71123
BPrognosticSupportsPoor OutcomeHead And Neck Squamous Cell Carcinoma3
BPredictiveDoes Not SupportSensitivity/ResponseLung Non-small Cell CarcinomaAdjuvant Chemotherapy2
BPredictiveSupportsSensitivity/ResponseSarcomaPazopanib2