CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/G466V

G466V

CIViC ID: 2222 · Gene: BRAF

Variant Summary

Also known as
GLY466VAL,RS121913351
HGVS
NC_000007.13:g.140481411C>A,NM_004333.4:c.1397G>T,NP_004324.2:p.Gly466Val,ENST00000288602.6:c.1397G>T
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level C: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = BRAF and variant = G466V.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseColorectal CancerIrinotecan,Panitumumab3
DPredictiveDoes Not SupportSensitivity/ResponseColorectal CancerVemurafenib3
DPredictiveDoes Not SupportSensitivity/ResponseSolid TumorVemurafenib3
CPredictiveDoes Not SupportSensitivity/ResponseCancerVemurafenib2