Variant Summary
- Also known as
- TYR375CYS,RS121913485,Y375C,TYR373CYS
- HGVS
- NC_000004.11:g.1806099A>G,NM_001163213.1:c.1124A>G,NP_000133.1:p.Tyr373Cys,NM_000142.5:c.1118A>G,NC_000004.12:g.1804372A>G
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 1Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = FGFR3 and variant = Y373C.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Does Not Support | Resistance | Cancer | R3Mab | 3 |
| B | Diagnostic | Supports | Positive | Bladder Carcinoma | 3 | |
| D | Oncogenic | Supports | Oncogenicity | Urinary Bladder Cancer | 3 |