Variant Summary
- Also known as
- K27M
- HGVS
- ENST00000366813.1:c.83A>T,ENSP00000355778.1:p.Lys28Met
- Variant Type(s)
- non_conservative_missense_variant
- Evidence Items
- 4
Evidence Level Distribution
Level B: 4
Evidence Items
Showing CIViC evidence rows where gene = H3-3A and variant = K28M.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Glioma | Dordaviprone | 4 |
| B | Diagnostic | Supports | Positive | Brain Glioblastoma Multiforme | 3 | |
| B | Diagnostic | Supports | Positive | Diffuse Midline Glioma, H3 K27M-mutant | 3 | |
| B | Diagnostic | Supports | Positive | Diffuse Midline Glioma, H3 K27M-mutant | 3 |