Variant Summary
- Also known as
- RS1801133,C677T,ALA222VAL
- HGVS
- NM_005957.4:c.665C>T,NP_005948.3:p.Ala222Val,ENST00000376592.1:c.665G>A,NC_000001.10:g.11856378G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 3
Evidence Items
Showing CIViC evidence rows where gene = MTHFR and variant = A222V.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predisposing | Supports | Protectiveness | Pancreatic Cancer | 4 | |
| B | Predictive | Supports | Sensitivity/Response | Rectum Cancer | Fluorouracil | 4 |
| B | Predictive | Supports | Sensitivity/Response | Stomach Cancer | Fluorouracil | 3 |