Variant Summary
- Also known as
- T3435C,RS1045642,3435C-T,ILE1145=
- HGVS
- NM_000927.4:c.3435T>C,NP_000918.2:p.Ile1145=,NC_000007.13:g.87138645A>G,ENST00000265724.3:c.3435T>C
- Variant Type(s)
- synonymous_variant
- Evidence Items
- 2
Evidence Level Distribution
Level B: 2
Evidence Items
Showing CIViC evidence rows where gene = ABCB1 and variant = I1145I.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Prognostic | Supports | Better Outcome | Breast Cancer | 3 | |
| B | Predictive | Supports | Sensitivity/Response | Lung Non-small Cell Carcinoma | Cisplatin,Carboplatin | 2 |