Variant Summary
- Also known as
- CYS238TYR
- HGVS
- NC_000017.10:g.7577568C>T,NM_000546.5:c.713G>A,NP_000537.3:p.Cys238Tyr,ENST00000269305.4:c.713G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level D: 1Level E: 1
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = C238Y.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| E | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 | |
| D | Functional | Supports | Dominant Negative | 2 |