CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Overexpression

Overexpression

CIViC ID: 289 · Gene: ERBB3

Variant Summary

HGVS
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Variant Type(s)
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Evidence Items
4

Evidence Level Distribution

Level B: 2Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = ERBB3 and variant = Overexpression.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceCancerSelumetinib,HER2 Inhibitor CP-724,714,Gefitinib4
BPredictiveSupportsResistanceColorectal CancerCetuximab4
DPredictiveSupportsSensitivity/ResponseCancerSelumetinib,Afatinib3
BPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab Emtansine2