CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/A190T

A190T

CIViC ID: 2929 · Gene: PRPS1

Variant Summary

HGVS
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Variant Type(s)
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Evidence Items
4

Evidence Level Distribution

Level B: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = PRPS1 and variant = A190T.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceB-lymphoblastic Leukemia/lymphomaThioguanine,Mercaptopurine5
BPrognosticSupportsPoor OutcomeB-lymphoblastic Leukemia/lymphoma3
DPredictiveSupportsSensitivity/ResponseB-lymphoblastic Leukemia/lymphomaLometrexol,Mercaptopurine3
DPredictiveDoes Not SupportResistanceB-lymphoblastic Leukemia/lymphomaDaunorubicin,Methotrexate,Cytarabine,Asparaginase3