CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 300 · Gene: SMO

Variant Summary

HGVS
—
Variant Type(s)
coding_transcript_variant
Evidence Items
4

Evidence Level Distribution

Level B: 3Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = SMO and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveSupportsResistanceBasal Cell CarcinomaVismodegib4
DPredictiveSupportsSensitivity/ResponseBasal Cell CarcinomaPSI,Arsenic Trioxide4
BPredictiveSupportsResistanceBasal Cell CarcinomaVismodegib,Sonidegib2
BPredictiveDoes Not SupportSensitivity/ResponseCancerVismodegib2