CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/D835Y

D835Y

CIViC ID: 3011 · Gene: FLT3

Variant Summary

Also known as
ASP835TYR,RS121913488
HGVS
NC_000013.11:g.28018505C>A,NC_000013.10:g.28592642C>A,ENST00000241453.12:c.2503G>T,NM_004119.3:c.2503G>T,ENSP00000241453.7:p.Asp835Tyr,NP_004110.2:p.Asp835Tyr,LRG_457t1:c.2503G>T,NM_004119.2:c.2503G>T
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level D: 5

Evidence Items

Showing CIViC evidence rows where gene = FLT3 and variant = D835Y.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseLeukemiaLestaurtinib4
DPredictiveSupportsSensitivity/ResponseCancerGilteritinib4
DPredictiveSupportsSensitivity/ResponseCancerFLT3 Tyrosine Kinase Inhibitor TTT-3002,Midostaurin,Lestaurtinib,Crenolanib3
DPredictiveDoes Not SupportSensitivity/ResponseCancerPonatinib,AG1295,AGS324,Linifanib,Quizartinib,Sunitinib,Sorafenib,R406,KW24493
DPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaGilteritinib2