Variant Summary
- HGVS
- NM_005228.3:c.89_881del,NP_005219.2:p.Val30_Arg297delinsGly,NC_000007.13:g.55209979_55221845del
- Variant Type(s)
- disruptive_inframe_deletion
- Evidence Items
- 6
Evidence Level Distribution
Level B: 4Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = EGFR and variant = VIII.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Glioblastoma | Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor | 4 |
| B | Predictive | Supports | Sensitivity/Response | Glioblastoma | Gefitinib,Erlotinib | 3 |
| D | Predictive | Supports | Sensitivity/Response | High Grade Glioma | Erlotinib | 3 |
| B | Predictive | Supports | Sensitivity/Response | Glioblastoma | Rindopepimut | 3 |
| B | Predictive | Supports | Resistance | Head And Neck Squamous Cell Carcinoma | Docetaxel,Cetuximab | 2 |
| D | Predictive | Supports | Sensitivity/Response | Brain Glioma | Nimotuzumab | 1 |