Variant Summary
- Also known as
- R693,ARG882,ARG693
- HGVS
- —
- Variant Type(s)
- missense_variant
- Evidence Items
- 27
Evidence Level Distribution
Level B: 27
Evidence Items
Showing CIViC evidence rows where gene = DNMT3A and variant = R882.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 5 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 5 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 5 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 5 | |
| B | Predictive | Does Not Support | Resistance | Acute Myeloid Leukemia | Daunorubicin | 4 |
| B | Prognostic | Does Not Support | Acute Myeloid Leukemia | 4 | ||
| B | Predictive | Supports | Sensitivity/Response | Acute Myeloid Leukemia | Idarubicin | 4 |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Does Not Support | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Does Not Support | Acute Myeloid Leukemia | 4 | ||
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 4 | |
| B | Diagnostic | Supports | Negative | Acute Myeloid Leukemia | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Better Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 3 | |
| B | Diagnostic | Supports | Positive | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Does Not Support | Acute Myeloid Leukemia | 3 | ||
| B | Prognostic | Does Not Support | Poor Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Supports | Poor Outcome | Acute Myeloid Leukemia | 3 | |
| B | Prognostic | Does Not Support | Better Outcome | Acute Myeloid Leukemia | 2 |