Variant Summary
- Also known as
- D739Y,D754Y,RS121913468,ASP769TYR,D769Y,ASP754TYR,ASP739TYR
- HGVS
- ENST00000269571.5:c.2305G>T,NC_000017.10:g.37880261G>T,NM_004448.3:c.2305G>T,NP_004439.2:p.Asp769Tyr
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level C: 2Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = ERBB2 and variant = D769Y.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Neratinib | 4 |
| C | Predictive | Supports | Sensitivity/Response | Extramammary Paget Disease | Afatinib | 3 |
| C | Predictive | Supports | Sensitivity/Response | Peritoneal Carcinoma | Afatinib | 1 |