CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/L755S

L755S

CIViC ID: 39 · Gene: ERBB2

Variant Summary

Also known as
LEU755SER,L725S,L740S
HGVS
NC_000017.10:g.37880220T>C,ENST00000269571.5:c.2264T>C,NM_004448.3:c.2264T>C,NP_004439.2:p.Leu755Ser
Variant Type(s)
missense_variant
Evidence Items
6

Evidence Level Distribution

Level C: 1Level D: 5

Evidence Items

Showing CIViC evidence rows where gene = ERBB2 and variant = L755S.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceBreast CancerLapatinib5
DPredictiveSupportsSensitivity/ResponseBreast CancerNeratinib5
DPredictiveSupportsSensitivity/ResponseColon CancerNeratinib,Trastuzumab,Lapatinib4
DPredictiveSupportsResistanceCecum AdenocarcinomaCetuximab3
CPredictiveDoes Not SupportSensitivity/ResponseColorectal AdenocarcinomaLeucovorin,Trastuzumab,Fluorouracil3
DPredictiveSupportsResistanceCancerLapatinib2