Variant Summary
- HGVS
- —
- Variant Type(s)
- gene_variant,gain_of_function_variant
- Evidence Items
- 12
Evidence Level Distribution
Level B: 10Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = BRAF and variant = Mutation.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 4 | |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 4 | |
| D | Predictive | Supports | Sensitivity/Response | Cancer | Trametinib | 4 |
| B | Predictive | Does Not Support | Sensitivity/Response | Colorectal Cancer | Panitumumab,Cetuximab | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab,Chemotherapy | 3 |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 3 | |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Oxaliplatin | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Irinotecan | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Bevacizumab | 3 |
| B | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab | 3 |
| B | Prognostic | Supports | Poor Outcome | Colorectal Cancer | 3 | |
| D | Predictive | Supports | Resistance | Colorectal Cancer | Cetuximab | 2 |