CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

Y646N

CIViC ID: 4090 · Gene: EZH2

Variant Summary

Also known as
Y641N,TYR646ASN,TYR641ASN
HGVS
NC_000007.14:g.148811636A>T,NC_000007.13:g.148508728A>T,ENST00000320356.7:c.1936T>A,ENSP00000320147.2:p.Tyr646Asn,NM_004456.5:c.1936T>A,NP_004447.2:p.Tyr646Asn,NM_001203247.2:c.1921T>A,NP_001190176.1:p.Tyr641Asn,ENST00000460911.5:c.1921T>A,ENSP00000419711.1:p.Tyr641Asn
Variant Type(s)
missense_variant
Evidence Items
2

Evidence Level Distribution

Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = EZH2 and variant = Y646N.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DFunctionalSupportsGain of Function3
DFunctionalSupportsLoss of Function3