CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Kinase Domain Mutation

Kinase Domain Mutation

CIViC ID: 413 · Gene: ERBB2

Variant Summary

HGVS
—
Variant Type(s)
protein_altering_variant
Evidence Items
2

Evidence Level Distribution

Level C: 2

Evidence Items

Showing CIViC evidence rows where gene = ERBB2 and variant = Kinase Domain Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaTrastuzumab4
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaAfatinib3