CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Y772_A775DUP

Y772_A775DUP

CIViC ID: 414 · Gene: ERBB2

Variant Summary

Also known as
A775INSYVMA,P.A775_G776INSYVMA,P.E770_A771INSAYVM,TYR772_ALA775DUP,A775_G776INSYVMA,M774INSAYVM
HGVS
NC_000017.10:g.37880993_37880994insGCTTACGTGATG,NM_001005862.2:c.2224_2235dupTACGTGATGGCT,ENST00000269571.5:c.2314_2325dupTACGTGATGGCT,NC_000017.10:g.37880985_37880996dupTACGTGATGGCT
Variant Type(s)
inframe_insertion
Evidence Items
7

Evidence Level Distribution

Level A: 1Level B: 1Level C: 3Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = ERBB2 and variant = Y772_A775DUP.

LevelTypeDirectionSignificanceDiseaseDrugsRating
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaAfatinib4
DPredictiveSupportsSensitivity/ResponseLung CarcinomaAfatinib4
APredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaTrastuzumab Deruxtecan4
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaTrastuzumab Emtansine3
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaAfatinib3
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaAfatinib,Sirolimus3
BPredictiveDoes Not SupportSensitivity/ResponseLung Non-small Cell CarcinomaDacomitinib2