Variant Summary
- Also known as
- LEU265PRO,L273P,LEU273PRO,RS387907272
- HGVS
- NC_000003.11:g.38182641T>C,NP_002459.2:p.L265P,NM_002468.4:c.794T>C,ENST00000396334.3:c.794T>C
- Variant Type(s)
- missense_variant,gain_of_function_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 2Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = MYD88 and variant = L265P.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Lymphoplasmacytic Lymphoma | Ibrutinib | 4 |
| B | Prognostic | Supports | Better Outcome | Chronic Lymphocytic Leukemia | 2 | |
| D | Predictive | Supports | Sensitivity/Response | Lymphoplasmacytic Lymphoma | IMG-2005-5,IRAK-1/4 Inhibitor | 1 |