CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/G12V

G12V

CIViC ID: 425 · Gene: KRAS

Variant Summary

Also known as
GLY12VAL,RS121913529
HGVS
NM_004985.4:c.35G>T,NP_004976.2:p.Gly12Val,NC_000012.11:g.25398284C>A,ENST00000256078.4:c.35G>T
Variant Type(s)
missense_variant
Evidence Items
12

Evidence Level Distribution

Level B: 3Level C: 5Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = KRAS and variant = G12V.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceColorectal CancerCetuximab4
DPredictiveSupportsSensitivity/ResponseColorectal CancerDactolisib,Selumetinib3
BPredictiveSupportsResistanceColorectal CancerCetuximab3
CPredictiveSupportsResistanceColorectal CancerPanitumumab3
BPrognosticSupportsPoor OutcomeLung Non-small Cell Carcinoma3
CPredictiveDoes Not SupportResistanceCancerCrizotinib2
CPredictiveSupportsResistanceLung CancerGefitinib2
DPredictiveSupportsResistanceColorectal CancerRegorafenib Anhydrous2
CPredictiveSupportsResistanceColorectal CancerPanitumumab,Cetuximab2
BPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaSelumetinib,Docetaxel1
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaPalbociclib1
CPredictiveSupportsResistanceColorectal CancerPanitumumab0