CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Q61K

Q61K

CIViC ID: 427 · Gene: NRAS

Variant Summary

Also known as
GLN61LYS,RS121913254
HGVS
NM_002524.4:c.181C>A,NP_002515.1:p.Gln61Lys,NC_000001.10:g.115256530G>T,ENST00000369535.4:c.181C>A
Variant Type(s)
missense_variant
Evidence Items
7

Evidence Level Distribution

Level C: 2Level D: 5

Evidence Items

Showing CIViC evidence rows where gene = NRAS and variant = Q61K.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseNeuroblastomaBinimetinib,Everolimus3
CPredictiveSupportsResistanceColorectal CancerCetuximab,Chemotherapy3
DPredictiveSupportsSensitivity/ResponseColorectal CancerDactolisib,Selumetinib3
DPredictiveSupportsResistanceSkin MelanomaVemurafenib2
DPredictiveSupportsSensitivity/ResponseSkin MelanomaSelumetinib2
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaSelumetinib,Trametinib2
CPredictiveSupportsSensitivity/ResponseOvary Serous AdenocarcinomaTrametinib2