CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Fusion

Fusion

CIViC ID: 4299 · Gene: EML4::NTRK3

Variant Summary

Also known as
EML4-NTRK3
HGVS
—
Variant Type(s)
transcript_fusion
Evidence Items
15

Evidence Level Distribution

Level C: 13Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = EML4::NTRK3 and variant = Fusion.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DOncogenicSupportsOncogenicityCongenital Fibrosarcoma4
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaEntrectinib4
CDiagnosticSupportsPositiveCongenital Fibrosarcoma3
CDiagnosticSupportsPositiveCongenital Mesoblastic Nephroma3
DOncogenicSupportsOncogenicityColon Cancer3
CPredictiveSupportsSensitivity/ResponseHigh Grade GliomaLarotrectinib3
CDiagnosticSupportsPositiveCongenital Fibrosarcoma3
CPredictiveSupportsSensitivity/ResponsePapillary Thyroid CarcinomaEntrectinib2
CPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaEntrectinib2
CPredictiveSupportsSensitivity/ResponseCongenital FibrosarcomaEntrectinib2
COncogenicSupportsOncogenicityCervical Sarcoma1
COncogenicSupportsOncogenicityPancreatic Ductal Adenocarcinoma1
COncogenicSupportsOncogenicityColon Adenocarcinoma1
COncogenicSupportsOncogenicityGlioblastoma1
COncogenicSupportsOncogenicityPoorly Differentiated Thyroid Carcinoma1