CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/V777L

V777L

CIViC ID: 44 · Gene: ERBB2

Variant Summary

Also known as
V747L,V762L,VAL777LEU,RS121913471
HGVS
NM_004448.3:c.2329G>T,NP_004439.2:p.Val777Leu,ENST00000269571.5:c.2329G>T,NC_000017.10:g.37881000G>T
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level C: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = ERBB2 and variant = V777L.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseBreast CancerNeratinib5
DPredictiveSupportsSensitivity/ResponseColon CancerTrastuzumab,Neratinib,Lapatinib4
DPredictiveSupportsSensitivity/ResponseCancerLapatinib2
CPredictiveSupportsSensitivity/ResponseBreast CancerAfatinib1