CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/S492R

S492R

CIViC ID: 453 · Gene: EGFR

Variant Summary

Also known as
SER492ARG,RS1057519860
HGVS
ENST00000275493.2:c.1476C>A,NC_000007.13:g.55228009C>A,NP_005219.2:p.Ser492Arg,NM_005228.4:c.1476C>A
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level C: 2Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = EGFR and variant = S492R.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseColorectal CancerPanitumumab,Futuximab/Modotuximab Mixture4
DPredictiveSupportsResistanceColorectal CancerCetuximab4
CPredictiveSupportsResistanceColorectal CancerCetuximab4
CPredictiveSupportsSensitivity/ResponseColorectal CancerPanitumumab2