Variant Summary
- Also known as
- ARG451CYS,RS377567759
- HGVS
- NC_000007.13:g.55227884C>T,ENST00000275493.2:c.1351C>T,NM_001346898.1:c.1351C>T,NP_001333827.1:p.Arg451Cys
- Variant Type(s)
- missense_variant
- Evidence Items
- 1
Evidence Level Distribution
Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = EGFR and variant = R451C.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Colorectal Cancer | Cetuximab,Panitumumab,Futuximab/Modotuximab Mixture | 2 |