Variant Summary
- Also known as
- ASP538GLY
- HGVS
- NC_000006.11:g.152419926A>G,ENST00000206249.3:c.1613A>G,NM_000125.3:c.1613A>G,NP_000116.2:p.Asp538Gly
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 1Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = ESR1 and variant = D538G.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Fulvestrant,Tamoxifen | 5 |
| D | Predictive | Supports | Resistance | Breast Cancer | Hormone Therapy | 3 |
| B | Predictive | Does Not Support | Sensitivity/Response | Breast Cancer | Palbociclib,Letrozole | 2 |