Variant Summary
- HGVS
- —
- Variant Type(s)
- loss_of_function_variant
- Evidence Items
- 6
Evidence Level Distribution
Level B: 1Level D: 5
Evidence Items
Showing CIViC evidence rows where gene = STK11 and variant = Loss.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Lung Non-small Cell Carcinoma | Docetaxel,Selumetinib | 3 |
| D | Predictive | Does Not Support | Sensitivity/Response | Lung Non-small Cell Carcinoma | Everolimus,Sirolimus | 3 |
| B | Predisposing | Supports | Predisposition | Peutz-Jeghers Syndrome | 3 | |
| D | Predictive | Supports | Sensitivity/Response | Pancreatic Ductal Adenocarcinoma | Roflumilast | 2 |
| D | Predictive | Supports | Sensitivity/Response | Peutz-Jeghers Syndrome | Sirolimus | 1 |
| D | Predictive | Supports | Sensitivity/Response | Peutz-Jeghers Syndrome | Sirolimus | 1 |