Variant Summary
- Also known as
- GLY537ASN
- HGVS
- NC_000006.11:g.152419922T>A,ENST00000206249.3:c.1609T>A,NM_000125.3:c.1609T>A,NP_000116.2:p.Tyr537Asn
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = ESR1 and variant = Y537N.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Tamoxifen,Fulvestrant | 5 |
| D | Predictive | Supports | Resistance | Breast Cancer | Hormone Therapy | 3 |