CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Fusion

Fusion

CIViC ID: 5 · Gene: EML4::ALK

Variant Summary

Also known as
EML4-ALK
HGVS
—
Variant Type(s)
transcript_fusion
Evidence Items
8

Evidence Level Distribution

Level C: 4Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = EML4::ALK and variant = Fusion.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaWHI-P1545
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaRetaspimycin Hydrochloride,Crizotinib4
CPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaCrizotinib4
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaCrizotinib4
CPredictiveSupportsSensitivity/ResponseMalignant Pleural MesotheliomaAlectinib4
CPredictiveSupportsResistanceLung Acinar AdenocarcinomaErlotinib2
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaAlvespimycin,Crizotinib2
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaLorlatinib2