Variant Summary
- Also known as
- GLY537SER
- HGVS
- NC_000006.11:g.152419923A>C,ENST00000206249.3:c.1610A>C,NM_000125.3:c.1610A>C,NP_000116.2:p.Tyr537Ser
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = ESR1 and variant = Y537S.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Fulvestrant,Tamoxifen | 5 |
| D | Predictive | Supports | Resistance | Breast Cancer | Hormone Therapy | 3 |