CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 510 · Gene: PTEN

Variant Summary

HGVS
—
Variant Type(s)
protein_altering_variant
Evidence Items
6

Evidence Level Distribution

Level B: 1Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = PTEN and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveDoes Not SupportSensitivity/ResponseEndometrial CarcinomaEverolimus3
DPredictiveSupportsResistanceHead And Neck Squamous Cell CarcinomaTaselisib3
DPredictiveSupportsSensitivity/ResponseCancerIpatasertib3
DPredictiveSupportsSensitivity/ResponseProstate AdenocarcinomaAlpelisib,PI3Kbeta Inhibitor AZD8186,Enzalutamide3
DPredictiveDoes Not SupportSensitivity/ResponseHead And Neck CancerPictilisib,Tanespimycin2
CDiagnosticSupportsPositiveGlioblastoma2