CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Fusion

Fusion

CIViC ID: 513 · Gene: NPM1::ALK

Variant Summary

Also known as
T(2;5)(P23;Q35),NPM-ALK,NPM1-ALK
HGVS
—
Variant Type(s)
transcript_fusion
Evidence Items
3

Evidence Level Distribution

Level B: 1Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = NPM1::ALK and variant = Fusion.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseAnaplastic Large Cell LymphomaCrizotinib5
BPredictiveSupportsSensitivity/ResponseAnaplastic Large Cell LymphomaCrizotinib4
DPredictiveSupportsSensitivity/ResponseCancerCrizotinib2