Variant Summary
- Also known as
- ASN546LYS,RS779707422
- HGVS
- NM_023110.2:c.1638C>A,NP_075598.2:p.Asn546Lys,ENST00000341462.5:c.1638C>A,NC_000008.10:g.38274849G>T
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level C: 1Level E: 1
Evidence Items
Showing CIViC evidence rows where gene = FGFR1 and variant = N546K.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Supports | Sensitivity/Response | Pilocytic Astrocytoma | Pemigatinib | 3 |
| E | Predictive | Supports | Sensitivity/Response | Ewing Sarcoma Of Bone | Ponatinib | 2 |