CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/G12R

G12R

CIViC ID: 530 · Gene: KRAS

Variant Summary

Also known as
GLY12ARG,RS121913530
HGVS
NM_004985.4:c.34G>C,NP_004976.2:p.Gly12Arg,NC_000012.11:g.25398285C>G,ENST00000256078.4:c.34G>C
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level B: 1Level C: 2Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = KRAS and variant = G12R.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsPoor OutcomePancreatic Cancer4
DPredictiveSupportsResistanceColorectal CancerCetuximab4
CPredictiveSupportsResistanceColorectal CancerChemotherapy,Cetuximab3
DPredictiveSupportsResistanceColorectal CancerRegorafenib Anhydrous1
CPredictiveSupportsResistanceColorectal CancerPanitumumab0