CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Loss

Loss

CIViC ID: 554 · Gene: CDKN2A

Variant Summary

HGVS
—
Variant Type(s)
loss_of_function_variant
Evidence Items
10

Evidence Level Distribution

Level B: 3Level C: 1Level D: 6

Evidence Items

Showing CIViC evidence rows where gene = CDKN2A and variant = Loss.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsPoor OutcomeAcute Lymphoblastic Leukemia4
BPredictiveSupportsResistanceBladder Urothelial CarcinomaImmune Checkpoint Inhibitor3
DPredictiveSupportsSensitivity/ResponseRenal Cell CarcinomaPalbociclib3
DPredictiveSupportsSensitivity/ResponseSkin MelanomaPalbociclib3
DPredictiveSupportsSensitivity/ResponseOvarian CancerPalbociclib3
CPredictiveSupportsSensitivity/ResponseHer2-receptor Negative Breast CancerLetrozole,Palbociclib3
DPredictiveSupportsSensitivity/ResponseSkin MelanomaAlvocidib2
DPredictiveSupportsSensitivity/ResponseEwing SarcomaPalbociclib,Linsitinib2
DPredictiveSupportsSensitivity/ResponseDermatofibrosarcoma ProtuberansPalbociclib2
BPredictiveDoes Not SupportResistanceLung Non-small Cell CarcinomaPalbociclib2