CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/S768I

S768I

CIViC ID: 562 · Gene: EGFR

Variant Summary

Also known as
SER768ILE,RS121913465
HGVS
NC_000007.13:g.55249005G>T,ENST00000275493.2:c.2303G>T,NM_005228.4:c.2303G>T,NP_005219.2:p.Ser768Ile
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level C: 4Level D: 1

Evidence Items

Showing CIViC evidence rows where gene = EGFR and variant = S768I.

LevelTypeDirectionSignificanceDiseaseDrugsRating
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaErlotinib3
DPredictiveDoes Not SupportSensitivity/ResponseCancerErlotinib,Gefitinib3
CPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaGefitinib2
CPredictiveDoes Not SupportSensitivity/ResponseLung Non-small Cell CarcinomaErlotinib2
CPredictiveSupportsResistanceLung AdenocarcinomaErlotinib0